The strength of our institute is the full integration of basic, translational, and clinical research, along with the establishment of strong collaborations and networks of excellence with leading experts from the field at local and international level. We made major contributions to the field, supported by a long-standing track record, in the understanding of viral and metabolic pathogenesis of liver disease and their translation into clinical applications, including the development of novel preventive and therapeutic strategies. Our key aims are: unravel the cell circuits driving liver disease progression, develop innovative patient-derived models for liver disease,  characterize SARS-CoV-2 / HBV / HCV /HDV – hepatocytes interactions,  translate discoveries into novel therapeutic strategies.